Letter | Published:

Sex difference in ontogenesis of circadian adrenocortical rhythm in cortisone-primed rats



THE hormonal milieu in the neonatal period has profound influences on the morphological, biochemical and functional development of the brain1,2. Krieger reported that the administration of corticosteroid (dexamethasone or hydrocortisone) to 2–4-d-old rats suppressed the circadian rhythm of plasma corticosterone at 30 d of age3, whereas treatment at 12–14 d of age did not affect the rhythmicity. We have investigated whether the suppression of corticosterone rhythm results in its permanent derangement throughout adult life or merely indicates its delayed appearance. After this paper was submitted, Krieger published the results of a similar study4.

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    Schaprio, S., in Influence of Hormones on the Nervous Systems (edit. by Ford, D. H.), 63–73 (S. Karger, Basel, 1971).

  2. 2

    Vernadakis, A., and Woodbury, D. M., ibid., 85–97.

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    Krieger, D. T., Science, 178, 1205–1207 (1972).

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    Krieger, D. T., Neuroendocrinology, 16, 355–363 (1974).

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    Givner, M. L., and Guy Rochefort, J., Steroids, 6, 485–489 (1965).

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    Davidson, J. M., Jones, L. E., and Levine, S., Endocrinology, 82, 655–662 (1968).

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    Krieger, D. T., in Biological Rhythms and Endocrine Function (edit. by Hedlund, L. W., Franz, J. M., and Kenny, A. D.), 169–184 (Plenum, New York, 1975).

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    Gibbs, F. P., Am. J. Physiol., 219, 288–292 (1970).

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    Critchlow, V., Lieberlt, R. A., Bar-Sela, M., Moutcastle, W., and Lipscomb, H. S., Am. J. Physiol., 205, 807–815 (1963).

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    Ramaley, J. A., Steroids, 20, 185–197 (1972).

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    Ramaley, J. A., Steroids, 21, 597–608 (1973).

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    Kitay, J. I., in Functions of The Adrenal Cortex (edit. by McKerns, K. W.), 775–811 (Appleton–Century–Crofts, New York, 1968).

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    Hiroshige, T., Abe, K., Wada, S., and Kaneko, M., Neuroendocrinology, 11, 306–320 (1973).

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    Barraclough, C. A., in Neuroendocrinology (edit. by Martini, L., and Ganong, W. F.), 61–99 (Academic, New York, 1967).

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