Abstract
THERE have been reports of experimental induction of contact sensitivity to dinitrochlorobenzene (DNCB) and dinitrofluorobenzene by injection of dinitrophenol (DNP) conjugated to lymphoid cells1–3. The DNP group is known to be capable of acting as a hapten but it is difficult to apply the term ‘hapten’ to the case of inorganic metals which act as contact sensitisers since antibodies with specificity for the metal ions have not been demonstrated. This is hardly surprising in view of the small size of some of the metals implicated as sensitisers, yet metal salts have been shown to produce stimulation of lymphocytes from individuals with metal contact sensitivity4–6. The following experiments were designed to determine whether lymph node cells pulsed with beryllium were capable of inducing beryllium contact sensitivity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Baumgarten, A., and Geczy, A. F., Immunology, 19, 205–217 (1970).
McFarlin, D. E., and Balfour, B., Immunology, 25, 995–1009 (1973).
Polak, L., and Macher, E., Nature, 252, 748–749 (1974).
MacLeod, T. M., Hutchinson, F., and Raffle, E. J., Br. J. Derm., 82, 487–492 (1970).
Polak, L. and Frey, J. R., Int. Archs Allergy, 44, 161–171 (1974).
Jones, J. M., and Amos, H. E., Int. Archs Allergy, 46, 161–171 (1974).
Frey, J. R., and Wenk, P., Int. Archs Allergy, 11, 81–100 (1957).
Polak, L., Barnes, J. M., and Turk, J. L., Immunology, 14, 707–711 (1968).
Krivanek, N., and Reeves, A. L., Am. ind. Hyg. Ass. J., 33, 45–52 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JONES, J., AMOS, H. Antigen formation in metal contact sensitivity. Nature 256, 499–500 (1975). https://doi.org/10.1038/256499a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/256499a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.