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Implications for theories of anaesthesia of antagonism between anaesthetic and non-anaesthetic steroids

Nature volume 256, pages 179–182 (1975)Cite this article

Abstract

The non-anaesthetic steroid Δ16-alphaxalone antagonises the depressant action of the anaesthetic steroid alphaxalone on synaptic transmission. This antagonism is not predicted by classical theories of anaesthesia and therefore poses fundamental questions about the molecular basis of anaesthesia.

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Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, NW7 1AA

    C. D. Richards & T. R. Hesketh

  2. Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK

    C. D. Richards & T. R. Hesketh

Authors
  1. C. D. Richards
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  2. T. R. Hesketh
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Richards, C., Hesketh, T. Implications for theories of anaesthesia of antagonism between anaesthetic and non-anaesthetic steroids. Nature 256, 179–182 (1975). https://doi.org/10.1038/256179a0

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  • DOI: https://doi.org/10.1038/256179a0

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