Abstract
PARTICLES having the density of type-C RNA tumour viruses, possessing reverse transcriptase (RNA-directed DNA polymerase) activity, and containing high molecular weight RNA that shares a portion of its base sequences with the RNA of murine RNA tumour viruses, have been reported to be present in several types of human malignant tissues, but not in their normal counterparts (review, see ref. 1). The endogenous RNA→DNA synthetic capabilities of these particles were used in a simultaneous detection test2,3 to determine these parameters. Because of their similarity and relatedness to animal oncornaviruses, these particles are considered to be possible aetiological agents of human cancer2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Green, M., and Gerard, G. F., Progress in Nucleic Acid Research and Molecular Biology, 14, 187–334 (1974).
Axel, R., Gulati, S. C., and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 69, 3133–3137 (1972).
Gulati, S. C., Axel, R., and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 69, 2020–2024 (1972).
Gerard, G. F., Rottman, F., and Green, M., Biochemistry, 13, 1632–1641 (1974).
Gerard, G. F., Biochem. biophys. Res. Commun., 63, 706–711 (1975).
Spadari, S., and Weissbach, A., J. biol. Chem., 249, 5809–5815 (1974).
McCaffrey, R., Smoler, D. F., and Baltimore, D., Proc. natn. Acad. Sci. U.S.A., 70, 521–525 (1973).
Gerwin, B. J., Todaro, G. F., Zeve, V., Scolnick, E. M., and Aaronson, S. A., Nature, 228, 435–438 (1970).
Stromberg, K., J. Virol., 9, 684–697 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GERARD, G., LOEWENSTEIN, P., GREEN, M. et al. Detection of reverse transcriptase in human breast tumours with poly(Cm)·oligo(dG). Nature 256, 140–143 (1975). https://doi.org/10.1038/256140a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/256140a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
