Abstract
THERE is ample evidence that collagen is produced by fibroblasts1–5. Following biosynthesis in ribosomes, collagen is thought to be transported to the periphery by microtubules6 but very little is known about the biology of collagen in cell membranes. We report that collagen is membrane-bound, that it is patched and capped by anti-collagen sera, and that the mobility of membrane-bound collagen is influenced by temperature and vinca alkaloids. The identification of membrane-bound collagen as a fibroblast marker would augment existing definitions of these cells, and would perhaps allow the application of certain immunological techniques to study collagen secretion by manipulating membrane-bound collagen with antibodies, lymphocytes, and so on.
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FAULK, W., CONOCHIE, L., TEMPLE, A. et al. Immunobiology of membrane-bound collagen on mouse fibroblasts. Nature 256, 123–125 (1975). https://doi.org/10.1038/256123a0
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DOI: https://doi.org/10.1038/256123a0
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