Abstract
ONE of the major deficiencies in cancer medicine is the inability to detect low level malignant growth such as tumours at an early stage of development or residual malignant growth after therapy. Biochemical assays for malignancy have centred around carcinoembryonic antigen (CEA) and α-foetoprotein (AFP)1, both of which are proteins found normally in embryonic tissues and only at low levels in mature, normal adults. Adult human serum contains a set of proteins with affinity for DNA2 and, as we report here, foetal human serum contains additional DNA-binding proteins not observed in adult sera. Patients with a wide variety of malignant disorders have been assayed for their complement of serum DNA-binding proteins; foetal species were present in the majority of sera examined.
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HOCH, S., LONGMIRE, R. & HOCH, J. Unique DNA-binding protein in the serum of patients with various neoplasms. Nature 255, 560–562 (1975). https://doi.org/10.1038/255560a0
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DOI: https://doi.org/10.1038/255560a0
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