Abstract
WE have established1 that long-lasting, strain-specific unresponsiveness to H-2 incompatible skin allografts can be induced in 30–50% of adult CBA mice by pretreatment with a single injection of a crude extract of liver from the graft donor strain, combined with a dose of Bordetella pertussis vaccine and a short course of antilymphocyte serum (ALS). Lymphoid cells removed from mice bearing healthy well-established allografts were reactive against graft donor strain antigens when tested in mixed lymphocyte culture (MLC), cell-mediated lympholysis tests (CML) and in graft versus host assays (GvH)2. Haemagglutinating and cytotoxic antibodies specific for the donor strain were invariably absent from the serum of unresponsive mice although small quantities of IgGl antibodies have been detected by a more sensitive technique3. We have so far been unable to detect any strain-specific suppressive activity in sera using MLC, CML and GvH tests2 or when passively transferring sera to skin-grafted mice.
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KILSHAW, P., BRENT, L. & PINTO, M. Suppressor T cells in mice made unresponsive to skin allografts. Nature 255, 489–491 (1975). https://doi.org/10.1038/255489a0
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DOI: https://doi.org/10.1038/255489a0
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