Abstract
THE capillaries in the central nervous system (CNS) are unique with respect to their barrier mechanisms, preventing to a varying degree many types of substances from passing into the brain parenchyma from the blood. Such barriers exist also against the catecholamines and their immediate precursor, L-dopa1–3. As the blood–brain barriers serve to protect the central nervous elements against harmful substances in the circulation, it can be postulated that damage to or defects in the barriers could lead not only to functional disturbances but perhaps also to direct structural damage in the brain tissue.
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SVENDGAARD, NA., BJÖRKLUND, A., HARDEBO, JE. et al. Axonal degeneration associated with a defective blood–brain barrier in cerebral implants. Nature 255, 334–337 (1975). https://doi.org/10.1038/255334a0
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DOI: https://doi.org/10.1038/255334a0
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