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Human longevity at the cost of reproductive success


The disposable soma theory on the evolution of ageing states that longevity requires investments in somatic maintenance that reduce the resources available for reproduction1,2. Experiments in Drosophila melanogaster indicate that trade-offs of this kind exist in non-human species3,4,5,6,7. We have determined the interrelationship between longevity and reproductive success in Homo sapiens using a historical data set from the British aristocracy. The number of progeny was small when women died at an early age, increased with the age of death, reaching a plateau through the sixth, seventh and eighth decades of life, but decreased again in women who died at an age of 80 years or over. Age at first childbirth was lowest in women who died early and highest for women who died at the oldest ages. When account was taken only of women who had reached menopause, who were aged 60 years and over, female longevity was negatively correlated with number of progeny and positively correlated with age at first childbirth. The findings show that human life histories involve a trade-off between longevity and reproduction.

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Figure 1
Figure 2: Point estimates of progeny number for married aristocratic women fromdifferent birth cohorts as a function of age at death.


  1. 1

    Kirkwood, T. B. L. Evolution of ageing. Nature 270, 301–304 (1977).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Kirkwood, T. B. L. & Rose, M. R. Evolution of senescence: late survival sacrificed for reproduction. Phil. Trans. R. Soc. Lond. B 332, 15–24 (1991).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Partridge, L. & Barton, N. H. Optimality, mutation and the evolution of ageing. Nature 362, 305–311 (1993).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Zwaan, B. J., Bijlsma, R. & Hoekstra, R. F. Direct selection of life span in Drosophila melanogaster. Evolution 49, 649–659 (1995).

    Article  Google Scholar 

  5. 5

    Fowler, K. & Partridge, L. Acost of mating in female fruitflies. Nature 338, 760–761 (1989).

    ADS  Article  Google Scholar 

  6. 6

    Prowse, N. & Partridge, L. The effects of reproduction on longevity and fertility in male Drosophila melanogaster. J. Insect Physiol. 43, 501–512 (1997).

    CAS  Article  Google Scholar 

  7. 7

    Chapman, T., Liddle, L. F., Kalb, J. M., Wolfner, M. F. & Partridge, L. Cost of mating in Drosophila melanogaster is mediated by male accessory-gland products. Nature 373, 241–244 (1995).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Finch, C. E. Longevity, Senescence, and the Genome(Univ. Chicago Press, Chicago, 1990).

    Google Scholar 

  9. 9

    Vaupel, J. W. et al. Biodemographic trajectories of longevity. Science 280, 855–860 (1998).

    CAS  Article  Google Scholar 

  10. 10

    Hollingwood, T. H. Mortality in the British peerage families since 1600. Population 18 (suppl.), 323–351 (1977).

    Google Scholar 

  11. 11

    Khoury, M. J., Beaty, T. H. & Cohen, B. H. Fundamentals of Genetic Epidemiology(Oxford Univ. Press, New York, 1993).

    Google Scholar 

  12. 12

    Finch, C. E. & Tanzi, R. E. Genetics of aging. Science 278, 407–411 (1997).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Gavrilova, N. S. et al. Evolution, mutations, and human longevity: European royal and noble families. Hum. Biol. 70, 799–804 (1998).

    CAS  PubMed  Google Scholar 

  14. 14

    Medawar, P. B. An Unsolved Problem of Biology(Lewis, London, 1952).

    Google Scholar 

  15. 15

    Williams, G. C. Pleiotropy, natural selection and the evolution of senescence. Evolution 11, 398–411 (1957).

    Article  Google Scholar 

  16. 16

    Charlesworth, B. Evolution in Age-structured Populations(Cambridge Univ. Press, Cambridge, 1994).

    Book  Google Scholar 

  17. 17

    Service, P. M., Hutchinson, E. W., MacKinley, M. D. & Rose, M. R. Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence. Physiol. Zool. 58, 380–389 (1985).

    Article  Google Scholar 

  18. 18

    Perls, T. T., Alpert, L. & Fretts, R. C. Middle-aged mothers live longer. Nature 389, 133 (1997).

    ADS  CAS  Article  Google Scholar 

  19. 19

    Townsend, P. Burke's Genealogical and Heraldic History of the Peerage Baronetage and Knightage(Burke's Peerage, London, 1963).

    Google Scholar 

  20. 20

    Gibbs, V., Doubleday, H. A., De Walden, H. & White, G. H. The Complete Peerage of England, Scotland, Ireland, Great Britain and the United Kingdom(St Catherine, London, 1910–1959).

  21. 21

    Kidd, C. & Williamson, D. Debrett's Peerage and Baronetage(Macmillan, London, 1994).

    Google Scholar 

  22. 22

    Paget, G. The Lineage and Ancestry of HRH Prince Charles, Prince of Wales(Skilton, Edinburgh, 1977).

    Google Scholar 

  23. 23

    Whittaker's Almanack(Whittaker, London, 1996).

  24. 24

    Moncreiffe, I. Royal Highness, Ancestry of the Royal Child(Hamish Hamilton, London, 1982).

    Google Scholar 

  25. 25

    Morby, J. E. The Wordsworth Handbook of Kings and Queens(Wordsworth Editors, Grasmere, 1994).

    Google Scholar 

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This work was supported by NESTOR. We thank L. Gavrilov and N. Gavrilova for identifying the database, J. Bloore for computerizing the genealogical data, and J. Vandenbroucke for critical comments on the manuscript.

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Correspondence to Rudi G. J. Westendorp.

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Westendorp, R., Kirkwood, T. Human longevity at the cost of reproductive success. Nature 396, 743–746 (1998).

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