Abstract
THE blood vessels of allografted organs are important sites for immunological injury1–3. In vivo, this is thought to be the result of interactions between antigenic determinants on donor vessel endothelium and recipient immunocompetent cells and antibodies. In vitro, damage to cultured pig endothelium by cytotoxic xeno- and alloantisera in the presence of rabbit complement has previously been described4. In addition, both canine5 and human6 endothelial cells are capable of stimulating allogeneic lymphocytes to blastogenesis and DNA synthesis, thus demonstrating the ability of endothelium to initiate directly an immunoproliferative response in vitro.
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HIRSCHBERG, H., THORSBY, E. & ROLSTAD, B. Antibody-induced cell-mediated damage to human endothelial cells in vitro. Nature 255, 62–64 (1975). https://doi.org/10.1038/255062b0
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DOI: https://doi.org/10.1038/255062b0
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