Letter | Published:

Mitigation of virus-induced foetal growth retardation in mice by dietary casein hydrolysate

Abstract

EXPERIMENTAL infection of pregnant mice with Coxsackievirus B3 induces retarded foetal growth and development of the plasma proteins1,2. Subsequent work in mice indicated that the clinically mild illness induced by the virus in the mother may be largely responsible for the impaired foetal development, even though a direct effect of the virus in the foetus could not be ruled out3. The infection resulted in maternal pancreatitis within 2 d, with the animals being incapable of digesting adequate amounts of important dietary constituents, notably proteins, to maintain normal foetal growth4, in spite of a higher intake of food by the infected mothers. We concluded that the pancreatic lesions resulted in infected animals being deprived of essential dietary proteins, and therefore determined whether the effects of the pathogen could be mitigated or perhaps overcome by the administration of a readily assimilable diet.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Coid, C. R., and Ramsden, D. B., Nature, 241, 460 (1973).

  2. 2

    Coid, C. R., Ramsden, D. B., and Healy, M. R. J., Med. Microbiol. Immun., 159, 285 (1974).

  3. 3

    Lansdown, A. B. G., and Coid, C. R., Br. J. exp. Pathol. 55, 101 (1974).

  4. 4

    Lansdown, A. B. G., and Ellaby, S. J., Histochemistry, 40, 175 (1974).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.