Letter | Published:

Appearance of β globin synthesis in erythroid cells of Ferrara β°-thalassaemic patients following blood transfusion

Naturevolume 254pages256259 (1975) | Download Citation

Subjects

Abstract

HOMOZYGOUS β-thalassaemic subjects from the Ferrara region characteristically do not synthesise β globin1,2. Some of us have presented previously data which suggest that the addition of ribosome-free supernatant isolated from red blood cells of normal adult individuals or from subjects with homozygous haemoglobin S to Ferrara thalassaemic ribosomal material induces βA globin synthesis3; these results suggested that this de novo synthesis was not associated with free normal βA globin mRNA. From these findings it has been concluded that the mutation of the Ferrara β thalassaemia does not reside inthe gene for β globin, which is in fact transcribed into normal β globin mRNA; but in a gene coding for a previously unrecognised factor, indispensable for β globin translation. Here we report data which suggest that the reticulocytes from these patients synthesise β globin following normal blood transfusion.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bargellesi, A., Pontremoli, S., and Conconi, F., Eur. J. Biochem., 1, 71 (1967).

  2. 2

    Conconi, F., et al., Nature, 217, 259 (1968).

  3. 3

    Conconi, F., Rowley, P. T., del Senno, L., Pontremoli, S., and Volpato, S., Nature new Biol., 238, 83 (1972).

  4. 4

    Allen, D. A., Schroeder, W. A., and Balog, G., J. Am. chem. Soc., 80, 1628 (1958).

  5. 5

    Rossi-Fanelli, A., Antonini, E., and Caputo, A., Biochim. bipphys. Acta, 30, 608 (1958).

  6. 6

    Wood, W. G., Whittaker, J. H., Clegg, J. B., and Weatherall, D. J., Biochim. biophys. Acta, 277, 413 (1972).

  7. 7

    Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. molec. Biol., 19, 91 (1966).

  8. 8

    Rieder, R. F., J. clin. Invest., 51, 364 (1972).

  9. 9

    Jones, R. T., Cold Spring Harb. Symp. quant. Biol., 29, 297 (1964).

  10. 10

    Schroeder, W. A., and Robberson, B., Analyt. Chem., 37, 1583 (1965).

  11. 11

    Renkonen, K. O., Ann. Med. exp. fenn., 26, 66 (1948).

  12. 12

    Boyd, W. C., and Reguera, R. M., J. Immun., 62, 333 (1949).

  13. 13

    Bray, G. A., Analyt. Biochem., 1, 269 (1960).

Download references

Author information

Affiliations

  1. Centro di Studi Biochimici sul Morbo di Cooley, Cassa di Risparmio di Ferrara, c/o Istituto di Chimica Biologica, Universitá degli Studi di Ferrara, Ferrara, Italy

    • FRANCESCO CONCONI
    • , LAURA DEL SENNO
    •  & PIERO FERRARESE
  2. Servizio Emodiagnostico e Trasfusionale, Arcispedale Sant'Anna, Ferrara, Italy

    • CESARE MENINI
  3. Divisione Pediatrica, Arcispedale Sant'Anna, Ferrara, Italy

    • LUIGI BORGATTI
    •  & CALOGERO VULLO
  4. Institut de Pathologie Moléculaire, Groupe U 15 de l'INSERM, Paris, France

    • DOMINIQUE LABIE

Authors

  1. Search for FRANCESCO CONCONI in:

  2. Search for LAURA DEL SENNO in:

  3. Search for PIERO FERRARESE in:

  4. Search for CESARE MENINI in:

  5. Search for LUIGI BORGATTI in:

  6. Search for CALOGERO VULLO in:

  7. Search for DOMINIQUE LABIE in:

About this article

Publication history

Received

Revised

Issue Date

DOI

https://doi.org/10.1038/254256a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.