Letter | Published:

Amino acid transport defect in glutathione-deficient sheep erythrocytes

Naturevolume 254pages156157 (1975) | Download Citation

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Abstract

THE tripeptide, reduced glutathione (GSH), is present in high concentration in mammalian red blood cells, where its major role is thought to be the protection of the cell against oxidative damage. Congenital red cell GSH deficiency has been reported in man, and attributed to a decreased activity of either of the two enzymes (γ glutamyl cysteine synthetase (GCS) or GSH synthetase (GSHS)) involved in GSH biosynthesis1. Such GSH-deficient red cells have a markedly diminished lifespan, and an increased susceptibility to the haemolytic action of oxidant drugs1.

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References

  1. 1

    Beutler, E., Adv. Metab. Disord., 6, 131–160 (1972).

  2. 2

    Smith, J. E., and Osburn, B. I., Science, 158, 374–375 (1967).

  3. 3

    Tucker, E. M., and Kilgour, L., Experientia, 26, 203–204 (1970).

  4. 4

    Tucker, E. M., and Kilgour, L., J. agric. Sci., Camb., 79, 515–516 (1972).

  5. 5

    Ellory, J. C., Tucker, E. M., and Deverson, E. V., Biochim. biophys. Acta, 279, 481–483 (1972).

  6. 6

    Young, J. D., Nimmo, I. A., and Hall, J. G., Biochem. Soc. Trans., 2, 314–317 (1974).

  7. 7

    Tucker, E. M., Res. vet. Sci., 16 19–22 (1974).

  8. 8

    Tucker, E. M., and Kilgour, L., Res. vet. Sci., 14, 306–311 (1973).

  9. 9

    Winter, C. G., and Christensen, H. N., J. biol. Chem., 239, 872–878 (1964).

  10. 10

    Prins, H. K., Oort, M., Loos, J. A., Zurcher, C., Blood, 27 145–166 (1966).

  11. 11

    Strumeyer, D. H., thesis, Harvard Univ. (1959).

  12. 12

    Rathbun, W. B., Archs Biochem. Biophys., 122, 73–84 (1967).

  13. 13

    Smith, J. E., Am. J. vet. Res., 34, 847–848 (1973).

  14. 14

    Bray, G. A., Analyt. Biochem., 1, 279–285 (1960).

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Affiliations

  1. ARC Institute of Animal Physiology, Babraham, Cambridge, CB2 4AT, UK

    • J. D. YOUNG
    • , J. C. ELLORY
    •  & ELIZABETH M. TUCKER

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https://doi.org/10.1038/254156a0

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