Abstract
THE tripeptide, reduced glutathione (GSH), is present in high concentration in mammalian red blood cells, where its major role is thought to be the protection of the cell against oxidative damage. Congenital red cell GSH deficiency has been reported in man, and attributed to a decreased activity of either of the two enzymes (γ glutamyl cysteine synthetase (GCS) or GSH synthetase (GSHS)) involved in GSH biosynthesis1. Such GSH-deficient red cells have a markedly diminished lifespan, and an increased susceptibility to the haemolytic action of oxidant drugs1.
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YOUNG, J., ELLORY, J. & TUCKER, E. Amino acid transport defect in glutathione-deficient sheep erythrocytes. Nature 254, 156–157 (1975). https://doi.org/10.1038/254156a0
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DOI: https://doi.org/10.1038/254156a0
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