Letter | Published:

Drugs blocking the muscle-damaging effects of 5-HT and noradrenaline in aorta-ligatured rats

Naturevolume 254pages151152 (1975) | Download Citation



USING an animal system proposed as a model for the hypothesis that Duchenne muscular dystrophy might be caused by an impaired blood supply within muscle1–3, we have found that certain drugs prevent the muscle damage typical of this disease. The model involves combining ligature of the aorta with a minimal dose of serotonin (5-hydroxytryptamine, 5-HT) or noradrenaline to produce myopathy of the lower extremities, which is evident in histochemical changes3 and increased amounts of some muscle enzymes in the plasma4.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Engel, W. K., in Neurohistochemistry (edit. by Adams, C.), 622–672 (Elsevier, Amsterdam, 1965); Pediatr. Clin. North Am., 14, 963–995 (1967); Rev. Neurol. Paris, 124, 291–298 (1971); in The Striated Muscle, 453–472 (Williams and Wilkins, Baltimore, 1973).

  2. 2

    Hathaway, P. W., Engel, W. K., and Zellweger, H., Archs Neurol., 22., 365–376 (1970).

  3. 3

    Mendell, J. R., Engel, W. K., and Derrer, E. C., Science, 172, 1143–1145 (1971).

  4. 4

    Mendell, J. R., Engel, W. K., and Derrer, E. C., Nature, 239, 522–524 (1972).

  5. 5

    Quastel, D. M. J., and Hackett, J. T., in The Structure and Function of Muscle, IV (edit. by Bourne, G. H.), 2–153 (Academic Press, New York, 1973).

  6. 6

    Goodman, L. S., and Gilman, A., in The Pharmacological Basis of Therapeutics, fourth ed. (Macmillan, New York, 1970).

  7. 7

    Sourkes, T. L., in Basic Neurochemistry (edit. by Albers, R. W., Siegel, G. J., Katzman, R., and Agranoff, B. W.), ch. 29, 581 (Little, Brown, Boston, 1972).

  8. 8

    Axelrod, J., Seminars in Psychiat., 4, 199–210 (1972).

  9. 9

    Whelan, R. F., in Control of the Peripheral Circulation in Man (Thomas, Springfield, Illinois, 1967).

  10. 10

    Chase, T. N., and Murphy, D. L., in Ann. Rev. Pharmac. (edit. by Elliott, H. W., Okun, R., and George, R.), 13, 181–197 (Annual Reviews, Inc., Palo Alto, California, 1973).

  11. 11

    Parker, J. M., and Mendell, J. R., Nature, 247, 103–104 (1974).

Download references

Author information


  1. Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, 20014



  1. Search for W. KING ENGEL in:

  2. Search for E. CAROLYN DERRER in:

About this article

Publication history



Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.