Letter | Published:

Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant

Naturevolume 254pages7879 (1975) | Download Citation



IT is generally believed that the B cells produce antibody against certain antigens after the helper cells recognise a determinant on the carrier part of the antigen. The immune response in mice against several antigens is controlled by Ir-genes which map in the major histocompatibility (H-2) locus of the IXth mouse linkage group. Details of the function of the Ir-genes are still unknown, but it is generally accepted that they control the recognition of carrier determinants1,2.

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  1. Immunology Unit, Division of Biology, University of Konstanz, D-775, Konstanz, Germany



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