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Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant

Nature volume 254, pages 78–79 (1975)Cite this article

Abstract

IT is generally believed that the B cells produce antibody against certain antigens after the helper cells recognise a determinant on the carrier part of the antigen. The immune response in mice against several antigens is controlled by Ir-genes which map in the major histocompatibility (H-2) locus of the IXth mouse linkage group. Details of the function of the Ir-genes are still unknown, but it is generally accepted that they control the recognition of carrier determinants1,2.

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References

  1. Benacerraf, B., and McDevitt, H. O., Science, 175, 273–279 (1972).

    Article  ADS  CAS  Google Scholar 

  2. McDevitt, H.O. and Landy, M. (eds), Genetic control of the immune responsiveness (Academic, New York, 1972).

  3. Keck, K., Grossberg, A. L., and Pressman, D., Immunochemistry, 10, 331–335 (1973).

    Article  CAS  Google Scholar 

  4. Schlichtkrull, J., Brange, J., Christiansen, A. H., Hallund, O., Heding, L. G., and Jorgensen, K. H., Diabetes, 21, (suppl. 2) 649–656 (1972).

    Article  CAS  Google Scholar 

  5. Root, M. A., Chance, R. E., and Galloway, J. A., Diabetes, 21, (suppl. 2) 657–660 (1972).

    Article  CAS  Google Scholar 

  6. Blumdell, T., Dodson, G., Hodgkin, D., and Mercola, D., Adv. Protein Chem., 26, 279 (1972).

    Article  Google Scholar 

  7. Rajewsky, K., and Mohr, R., Eur. J. Immun., 4, 111–119 (1974).

    Article  CAS  Google Scholar 

  8. Senyk, G., Williams, E. B., Nitecki, D. E., and Goodman, J. W., J. exp. Med., 133, 1294–1308 (1971).

    Article  CAS  Google Scholar 

  9. Kumar, D., Mehtalia, S. D., and Miller, L. V., Horm. Metab. Res., 6, 175–177 (1974).

    Article  CAS  Google Scholar 

  10. Thorsky, E., Transplant. Rev., 18, 51–129 (1974).

    Google Scholar 

  11. Meyer-Delius, M., Mitchison, N. A., Pitt-Rivers, R., and Rüde, E., Eur. J. Immun. 1, 267–271 (1971).

    Article  CAS  Google Scholar 

  12. Desbuquois, B., and Aurbach, G. D., J. Clin. Endocr., 33, 732–738 (1971).

    Article  CAS  Google Scholar 

Download references

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  1. Immunology Unit, Division of Biology, University of Konstanz, D-775, Konstanz, Germany

    KLAUS KECK

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  1. KLAUS KECK
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KECK, K. Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant. Nature 254, 78–79 (1975). https://doi.org/10.1038/254078a0

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