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Increased hyaluronic acid production on stimulation of DNA synthesis in chick embryo fibroblasts

Naturevolume 254pages6566 (1975) | Download Citation



STUDIES of differentiating tissues indicate that the characteristic products of differentiated cells begin to appear only after cell multiplication has slowed or stopped1. Therefore, it was concluded that cell multiplication and differentiated function are mutually exclusive. Although this conclusion was based mainly on studies of progressively developing tissues, it has been extended to cells which have already differentiated but have retained the capacity to multiply2. This is supported by some older studies of differentiated cells in culture3–5. There is growing evidence, however, from studies both in vitro6,7 and in vivo8, that cell multiplication and differentiated function are compatible in differentiated cells capable of multiplication. Here we add to that evidence by showing that the production of hyaluronic acid, a characteristic product of connective tissue, is positively correlated with the multiplication rate of chick embryo fibroblasts.

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  1. Department of Molecular Biology and Virus Laboratory, University of California, Berkeley, California, 94720

    •  & HARRY RUBIN


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