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Lipopolysaccharide induces C-type virus in short term cultures of BALB/c spleen cells

Naturevolume 254pages6061 (1975) | Download Citation

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Abstract

IN certain strains of mice, such as AKR, C-type viruses occur throughout life and can readily be detected by infectivity assays1,2. In other seemingly virus-free strains, C-type viruses can be activated in vivo by X irradiation3,4, chemical carcinogens5, graft-versus-host reactions6 and in vitro by long term cultivation7, by X rays8, halogenated pyrimidine analogues9,10 and mixed lymphocyte reactions6. We report here that lipopolysaccharide, a B-cell mitogen18, induces C-type virus in short term cultures of BALB/c spleen cells.

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References

  1. 1

    Gross, L., Natn. Cancer Inst. Mongr., 22, 407 (1966).

  2. 2

    Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., J. Virol., 3, 126 (1969).

  3. 3

    Kaplan, H. S., Cancer Res., 27, 1325 (1967).

  4. 4

    Haran-Ghera, N., Int. J. Cancer, 1, 81 (1966).

  5. 5

    Igel, H. J., Huebner, R. J., Turner, H. C., Kotin, P., and Falk, H. L., Science, 166, 1624 (1969).

  6. 6

    Hirsch, M. S., Phillips, S. M., Solnik, C., Black, P. H., Schwartz, R. S., and Carpenter, C. B., Proc. natn. Acad. Sci. U.S.A., 69, 1069 (1972).

  7. 7

    Aaronson, S. A., Hartley, J. W., and Todaro, G. J., Proc. natn. Acad. Sci. U.S.A., 64, 87 (1969).

  8. 8

    Rowe, W. P., Hartley, J. W., Lander, M. R., Pugh, W. E., and Teich, N., Virology, 46, 866 (1971).

  9. 9

    Lowy, D. R., Rowe, W. P., Teich, N., and Hartley, J. W., Science, 174, 155 (1971).

  10. 10

    Aaronson, S. A., Todaro, G. J., and Scolnick, E. M., Science, 174, 157 (1971).

  11. 11

    Schumann, G., Schnebli, H. P., and Dukor, P., Int. Archs Allergy appl. Immun., 45, 331 (1973).

  12. 12

    Wu, A. M., Ting, R. C., Paran, M., and Gallo, R. C., Proc. natn. Acad. Sci. U.S.A., 69, 3820 (1972).

  13. 13

    Goodman, N. C. and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 68, 2203 (1971).

  14. 14

    Robert, M. S., Smith, R. G., Gallo, R. C., Sarin, P. S., and Abrell, J. W., Science, 176, 798 (1972).

  15. 15

    Baltimore, D., and Smoler, D., Proc. natn. Acad. Sci. U.S.A., 68, 1507 (1971).

  16. 16

    McCaffrey, R., Smoler, D. F., and Baltimore, D., Proc. natn. Acad. Sci. U.S.A., 70, 521 (1973).

  17. 17

    Aaronson, S. A., and Stephenson, J. R., Proc. natn. Acad. Sci. U.S.A., 71, 1957 (1974).

  18. 18

    Gery, I., Krüger, J., and Spiesel, S. Z., J. Immun., 108, 1088 (1972).

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Affiliations

  1. Friedrich Miescher-Institut, Basel, Switzerland

    • CHRISTOPH MORONI
  2. Biological Research Laboratories, Pharmaceutical Division, CIBA-GEIGY Limited, Basel, Switzerland

    • GEBHARD SCHUMANN

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https://doi.org/10.1038/254060a0

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