Letter | Published:

Lipopolysaccharide induces C-type virus in short term cultures of BALB/c spleen cells

Naturevolume 254pages6061 (1975) | Download Citation



IN certain strains of mice, such as AKR, C-type viruses occur throughout life and can readily be detected by infectivity assays1,2. In other seemingly virus-free strains, C-type viruses can be activated in vivo by X irradiation3,4, chemical carcinogens5, graft-versus-host reactions6 and in vitro by long term cultivation7, by X rays8, halogenated pyrimidine analogues9,10 and mixed lymphocyte reactions6. We report here that lipopolysaccharide, a B-cell mitogen18, induces C-type virus in short term cultures of BALB/c spleen cells.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Gross, L., Natn. Cancer Inst. Mongr., 22, 407 (1966).

  2. 2

    Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., J. Virol., 3, 126 (1969).

  3. 3

    Kaplan, H. S., Cancer Res., 27, 1325 (1967).

  4. 4

    Haran-Ghera, N., Int. J. Cancer, 1, 81 (1966).

  5. 5

    Igel, H. J., Huebner, R. J., Turner, H. C., Kotin, P., and Falk, H. L., Science, 166, 1624 (1969).

  6. 6

    Hirsch, M. S., Phillips, S. M., Solnik, C., Black, P. H., Schwartz, R. S., and Carpenter, C. B., Proc. natn. Acad. Sci. U.S.A., 69, 1069 (1972).

  7. 7

    Aaronson, S. A., Hartley, J. W., and Todaro, G. J., Proc. natn. Acad. Sci. U.S.A., 64, 87 (1969).

  8. 8

    Rowe, W. P., Hartley, J. W., Lander, M. R., Pugh, W. E., and Teich, N., Virology, 46, 866 (1971).

  9. 9

    Lowy, D. R., Rowe, W. P., Teich, N., and Hartley, J. W., Science, 174, 155 (1971).

  10. 10

    Aaronson, S. A., Todaro, G. J., and Scolnick, E. M., Science, 174, 157 (1971).

  11. 11

    Schumann, G., Schnebli, H. P., and Dukor, P., Int. Archs Allergy appl. Immun., 45, 331 (1973).

  12. 12

    Wu, A. M., Ting, R. C., Paran, M., and Gallo, R. C., Proc. natn. Acad. Sci. U.S.A., 69, 3820 (1972).

  13. 13

    Goodman, N. C. and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 68, 2203 (1971).

  14. 14

    Robert, M. S., Smith, R. G., Gallo, R. C., Sarin, P. S., and Abrell, J. W., Science, 176, 798 (1972).

  15. 15

    Baltimore, D., and Smoler, D., Proc. natn. Acad. Sci. U.S.A., 68, 1507 (1971).

  16. 16

    McCaffrey, R., Smoler, D. F., and Baltimore, D., Proc. natn. Acad. Sci. U.S.A., 70, 521 (1973).

  17. 17

    Aaronson, S. A., and Stephenson, J. R., Proc. natn. Acad. Sci. U.S.A., 71, 1957 (1974).

  18. 18

    Gery, I., Krüger, J., and Spiesel, S. Z., J. Immun., 108, 1088 (1972).

Download references

Author information


  1. Friedrich Miescher-Institut, Basel, Switzerland

  2. Biological Research Laboratories, Pharmaceutical Division, CIBA-GEIGY Limited, Basel, Switzerland



  1. Search for CHRISTOPH MORONI in:

  2. Search for GEBHARD SCHUMANN in:

About this article

Publication history


Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.