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Decrease in 17β-oestradiol receptor in brain of ageing rats


WE have shown1,2 that the administration of 17β-oestradiol to ovariectomised female raits induces acetylcholinesterase (AChE; EC in the cerebral hemisphere and cerebellum, and that this induction decreases with increasing age. The greatest induction occurs in the immature rat, and there is no induction in the old. As 17β-oestradiol receptors are present in rat brain3,4, we suggested that the impairment of AChE induction in the brain of old rats may be due to a decrease in the level of this receptor. This study was designed to test our hypothesis, and the data show for the first time that it may be correct.

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  1. Moudgil, V. K., and Kanungo, M. S., Biochem. biophys. Res. Commun., 52, 725 (1973).

    Article  CAS  Google Scholar 

  2. Moudgil, V. K., and Kanungo, M. S., Biochim. biophys. Acta, 329, 211 (1973).

    Article  CAS  Google Scholar 

  3. Whalen, E. E., and Maurer, R. A., Proc. natn. Acad. Sci. U.S.A., 63, 681 (1969).

    Article  ADS  CAS  Google Scholar 

  4. Presl, J., Rahling, S., Horsky, J., and Herzmann, J., Endocrinology, 86, 899 (1970).

    Article  CAS  Google Scholar 

  5. Wong, M. D., and Burton, A. F., Biochem. biophys. Res. Commun., 50, 71 (1973).

    Article  CAS  Google Scholar 

  6. Sutherland, E. W., Cori, C. F., Haynes, R., and Olsen, N. S., J. biol. Chem., 180, 825 (1949).

    CAS  PubMed  Google Scholar 

  7. Finch, C. E., Foster, J. R., and Mirsky, A. E., J. gen. Physiol., 54, 690 (1969).

    Article  CAS  Google Scholar 

  8. Kanungo, M. S., and Gandhi, B. S., Proc. natn. Acad. Sci. U.S.A., 69, 2035 (1972).

    Article  ADS  CAS  Google Scholar 

  9. Rao, S. S., and Kanungo, M. S., Mech. Age. Devl., 1, 61 (1972).

    Article  CAS  Google Scholar 

  10. Kanungo, M. S., Biochem. Rev., 41, 13 (1970).

    CAS  Google Scholar 

  11. Kanungo, M. S., J. theoret. Biol. (in the press).

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KANUNGO, M., PATNAIK, S. & KOUL, O. Decrease in 17β-oestradiol receptor in brain of ageing rats. Nature 253, 366–367 (1975).

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