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Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells


WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells1–7.

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CALDERON, J., UNANUE, E. Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells. Nature 253, 359–361 (1975).

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