WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells1–7.
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CALDERON, J., UNANUE, E. Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells. Nature 253, 359–361 (1975). https://doi.org/10.1038/253359a0
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