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Sex and age differences in human platelet aggregation


MALES stand at risk in many pathological states1, especially cardiovascular disease, in which there is a statistically significant higher mortality in men than women2. We have described3 a sex difference in platelet responsivity in rats and guinea pigs where platelets from males were significantly more sensitive to aggregating stimuli than those from females. Increased platelet responsiveness has been detected in humans,in thromboembolic disease4 and after acute myocardial infarction5. Indeed, the principal post mortem finding in subjects who died suddenly is occlusion in the pulmonary circulation due to platelet aggregation6. We have suggested3 that platelet sensitivity is mediated by the androgenic steroids and that androgens contribute to the incidence of thrombotic disease.

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  1. Hamilton, J. B., Rec. prog. Hormone Res., 3, 257 (1948).

    CAS  Google Scholar 

  2. Final mortality statistics, 23 (National Center for Health Statistics, Department of Health Education and Welfare, Washington DC, 1971).

  3. Johnson, M., and Ramwell, P. W., The Physiologist, 17, 256 (1974).

    Google Scholar 

  4. Acheson, J., Danta, G., and Hutchinson, E. C., Atherosclerosis, 15, 123 (1972).

    Article  CAS  Google Scholar 

  5. Zahavi, J., and Dreyfuss, F., Thromb. Diathes. Haemorr., 21, 76 (1969).

    Article  CAS  Google Scholar 

  6. Pirkle, H., and Carstens, P., Science, 185, 1062 (1974).

    Article  ADS  CAS  Google Scholar 

  7. Dugdale, M., and Masi, A. T., Second Report on the Oral Contraceptives, 43 (Advisory Committee on Obstetrics and Gynecology, Food and Drug Administration, Washington DC, 1969).

    Google Scholar 

  8. Zahavi, J., Dreyfuss, F., Kalef, M., and Soferman, N., Am. J. Obstet. Gynec., 117, 107 (1973).

    Article  CAS  Google Scholar 

  9. Poller, L., Acta. med. scand. suppl., 525, 197 (1971).

    CAS  PubMed  Google Scholar 

  10. Caspary, E. A., and Peberdy, M., Lancet, i, 1142 (1965).

    Article  Google Scholar 

  11. Danta, G., Atherosclerosis, 11, 223 (1970).

    Article  CAS  Google Scholar 

  12. Furman, R. H., Ann. N. Y. Acad. Sci., 149, 822 (1968).

    Article  ADS  CAS  Google Scholar 

  13. Evans, G., Current concepts of cerebrovascular disease, stroke, 7, 25 (1972).

    Google Scholar 

  14. Levine, P. H., Circulation, 48, 619 (1973).

    Article  CAS  Google Scholar 

  15. O'Brien, J. R., Nature, 202, 188 (1964).

    Google Scholar 

  16. Shio, H., Plasse, A. M., and Ramwell, P. W., Microvasc. Res., 2, 294 (1970).

    Article  CAS  Google Scholar 

  17. Frojmovic, M. M., J. Lab. clin. Med., 82, 137 (1973).

    CAS  PubMed  Google Scholar 

  18. Morse, W. I., Harkness, R. A., Hogue, K. S., Ismail, A. A. A., and Nickerson, M., J. Atheroscler. Res., 8, 869 (1968).

    Article  CAS  Google Scholar 

  19. Turksoy, R. N., Phillips, L. L., and Southam, A. L., Am. J. Obstet. Gynec., 82, 1211 (1961).

    Article  CAS  Google Scholar 

  20. Bhargava, K. P., Dhawan, K. N., and Saxena, R. E., Br. J. Pharmac., 31, 26 (1967).

    CAS  Google Scholar 

  21. Barberia, J. M., Giner, J., Cortes-Gallegos, V., Steroids, 615 (1973).

  22. Mitchell, H. C., J. Lab. clin. Med., 79, 83 (1974).

    Google Scholar 

  23. Silver, M. J., Smith, J. B., Ingerman, C., and Kocsis, J. J., Prostaglandins, 4, 863 (1973).

    Article  CAS  Google Scholar 

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JOHNSON, M., RAMEY, E. & RAMWELL, P. Sex and age differences in human platelet aggregation. Nature 253, 355–357 (1975).

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