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Single-stranded regions in DNA of old mice


INVESTIGATIONS have shown that senescence is accompanied by molecular changes in the structure of the eukaryotic genome. Some of these changes have been reported to result in the loss of some genetic material in the brain cells of ageing beagles1. Furthermore, the molecular weight of rat liver DNA decreases as a function of senescence2. If such changes occurred on a large scale, the resulting genetic damage could affect severely some of the crucial gene functions of an organism. We are studying the physical state of the DNA of senescing mice, and report here the accumulation of an increasing amount of single-stranded regions in the DNA with age.

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CHETSANGA, C., BOYD, V., PETERSON, L. et al. Single-stranded regions in DNA of old mice. Nature 253, 130–131 (1975).

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