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Deficiency of the Y base in a hepatoma phenylalanine tRNA


THE structures of various tRNAs are of considerable interest as this type of RNA plays a central role in translation of the genetic code and has been shown in bacteria to function in cell regulation1,2. In the search for a possible role of tRNA in regulatory processes in higher organisms, a number of studies have compared chromatographic profiles of tRNA from different tissues, organs, tumours and cell cultures3. These studies have revealed that tumour cells frequently contain tRNA species which differ in their chromatographic mobility from the corresponding tRNAs present in normal adult tissues. Until now, however, no structural basis for these tRNA differences between normal and malignant tissues has been elucidated.

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GRUNBERGER, D., WEINSTEIN, I. & MUSHINSKI, J. Deficiency of the Y base in a hepatoma phenylalanine tRNA. Nature 253, 66–67 (1975).

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