Abstract
THE growth of human tumours in mice may be evaluated by node size and histological sections1–4. Because tumour cells may fuse with host cells5–7 in vivo, it is important to ascertain which cells produce the tumour. Human chromosomes may be identified using banding procedures and this makes it possible to verify that human cells alone grow in the tumour. If chromosomal analysis is performed on the tumour before injection, it would also be possible to determine which cells were able to grow rapidly in vivo. Here we present a report on such a chromosomal analysis of a human cervical carcinoma cell line grown in immunosuppressed mice and re-established in vitro.
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References
Stanbridge, E., and Perkins, F., Nature, 221, 80–81 (1969).
Franks, C., Curtis, K., Perkins, F., Br. J. Cancer, 27, 390–395 (1973).
Castro, J., Nature new Biol., 239, 83–84 (1972).
Castro, J., and Zanelli, J., Nature new Biol., 245, 51 (1973).
Goldenberg, D., Bhan, R., and Paria, R., Cancer Res., 31, 1148–1152 (1971).
Wiener, F., Fenyo, E., Klein, G., and Harris, H., Nature new Biol., 238, 155–159 (1972).
Lasfargus, E., Coutinho, W., and Moore, D., Cancer Res., 32, 2365–2368 (1972).
Sykes, J., Whitescarver, J., Jernstrom, P., Nolan, J., and Byatt, P., J. natn. Cancer Inst., 45, 107–122 (1970).
Stefos, K., and Arrighi, F., Expl Cell Res., 68, 228–231 (1971).
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BORDELON, M., STUBBLEFIELD, E. Human tumours in mice confirmed by chromosomal analysis. Nature 252, 324–326 (1974). https://doi.org/10.1038/252324a0
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DOI: https://doi.org/10.1038/252324a0
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