Abstract
THE lethal action of ionising radiation or alkylating drugs is thought to involve the formation of electrophilic species (many of which are free radical in nature) which interact with essential molecules such as nucleic acid. The protective effect of the nucleophilic compound, cysteamine, has been attributed to its ability, first, to scavenge these species thereby preventing their reaction or, second, to reduce chemically the free radical lesion thereby resulting in its repair1,2. A similar mechanism has been postulated to explain the protective effect of promethazine against carbon tetrachloride-induced liver damage3,4.
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WILLSON, R., WARDMAN, P. & ASMUS, KD. Interaction of dGMP radical with cysteamine and promethazine as possible model of DNA repair. Nature 252, 323–324 (1974). https://doi.org/10.1038/252323a0
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DOI: https://doi.org/10.1038/252323a0
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