Abstract
WE have reported that lentinan and several other polysaccharides inhibited the growth of sarcoma-180 transplanted subcutaneously in mice1–4, and that their antitumour activity is a host-mediated reaction with participation of the thymus or thymus-dependent cells (T cells)5–8. While it has recently been reported that lentinan is a T cell oriented adjuvant9 and a helper T cell stimulant10–11, it is not clear how lentinan affects the host at the first stage before the induction of many immunological changes. It is possible that the antitumour activity of lentinan is dependent on the presence of certain substances in the host which interact with these polysaccharides.
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References
Chihara, G., Maeda, Y. Y., Hamuro, J., Sasaki, T., and Fukuoka, F., Nature, 222, 687–688 (1969).
Chihara, G., Hamuro, J., Maeda, Y. Y., Arai, Y., and Fukuoka, F., Cancer Res., 30, 2776–2781 (1970).
Chihara, G., Hamuro, J., Maeda, Y. Y., Arai, Y., and Fukuoka, F., Nature, 225, 943–944 (1970).
Hamuro, J., Yamashita, Y., Ohsaka, Y., Maeda, Y. Y., and Chihara, G. Nature, 233, 486–487 (1971).
Maeda, Y. Y., and Chihara, G., Nature, 229, 634 (1971).
Maeda, Y. Y., Hamuro, J., and Chihara, G., Int. J. Cancer, 8, 41–46 (1971).
Maeda, Y. Y., and Chihara, G., Int. J. Cancer, 11, 153–161 (1973).
Maeda, Y. Y., Hamuro, J., Yamada, Y. O., Ishimura, K., and Chihara, G., Immunopotentiation, Ciba Found. Symp. New Series, 18, 259–286 (Elsevier, Exerpta Medica, North-Holland, Amsterdam, 1973).
Dresser, D. W., and Phillips, J. M. Immunopotentiation, Ciba Found. Symp. New Series, 18, 3–28 (Elsevier, Excerpta medica, North-Holland, Amsterdam, 1973).
Takatsu, K., Masaki, H., and Kitagawa, M., Proc. Jap. Cancer Ass., 32, 249 (1973).
Dennert, G., and Tucker, D., J. natn. Cancer Inst., 51, 1727–1729 (1973).
Pillemer, L., and Ross, O. A., Science, 121, 732–733 (1955).
Todd, E. W., Pillemer, L., and Lepow, I. H., J. Immun., 83, 418–427 (1959).
Pensky, J., Hinz, C. F., jun., Todd, E. W., Wedgwood, R. J., Boyer, J. T., and Lepow, I. H., J. Immun., 100, 142–158 (1968).
Okuda, T., Yoshioka, Y., Ikekawa, T., Chihara, G., and Nishioka, K., Nature new Biol., 238, 59–60 (1972).
Hamuro, J., and Chihara, G., Nature, 245, 40–41 (1973).
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MAEDA, Y., CHIHARA, G. & ISHIMURA, K. Unique increase of serum proteins and action of antitumour polysaccharides. Nature 252, 250–251 (1974). https://doi.org/10.1038/252250a0
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DOI: https://doi.org/10.1038/252250a0
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