Abstract
When grown in the absence of folate, Streptococcus faecalis initiates protein synthesis with non-formylated methionyl-tRNAfMet. The nucleotide sequence of this tRNA differs from that of tRNAfMet synthesised in the presence of folate — which functions as N-formyl-methionyl-tRNAfMet—only in the ‘GTψC’ loop, where uracil is found in the tRNAfMet of folate-free cells in place of thymine.
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Delk, A., Rabinowitz, J. Partial nucleotide sequence of a prokaryote initiator tRNA that functions in its non-formylated form. Nature 252, 106–109 (1974). https://doi.org/10.1038/252106a0
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DOI: https://doi.org/10.1038/252106a0
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