Abstract
THE rapid rejection of xenografts between widely different species, and the rapid ‘hyperacute’ rejection of vascularised allografts to previously sensitised recipients are both thought to be due to the effects of cytotoxic antibodies in recipient serum1,2. I have used cultured vascular endothelium to observe the direct effects of cytotoxic sera in vitro. Here I examine the effects on pig endothelium of dog serum (as a model for xenograft rejection) and of pig alloantisera to PLA antigens3 (as a model for hyperacute allograft rejection).
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References
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DE BONO, D. Effects of cytotoxic sera on endothelium in vitro. Nature 252, 83–84 (1974). https://doi.org/10.1038/252083a0
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DOI: https://doi.org/10.1038/252083a0
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