Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Dual mechanism for the action of cholesterol on membrane permeability

Abstract

CHOLESTEROL, which is a widespread component of the plasma membrane, has a substantial influence on the permeability properties of lipid bilayer1–3 and cell membranes4. Although the effects of cholesterol on membrane structure are increasingly well understood5 the mechanisms by which cholesterol modulates membrane permeability are obscure, mainly because it is difficult to deduce permeability properties from the knowledge of membrane structure alone.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Szabo, G., Eisenman, G., and Ciani, S., J. Memb. Biol., 1, 346 (1969).

    Article  CAS  Google Scholar 

  2. De Gier, J., Mardersloot, J. G., and Van Deenen, L. L. M., Biochim. biophys. Acta, 173, 143 (1969).

    Article  CAS  Google Scholar 

  3. Hladky, S. B., and Haydon, D. A., Biochim. biophys. Acta, 318, 464 (1973).

    Article  CAS  Google Scholar 

  4. Papahadjopoulos, D., J. theor. Biol., 43, 329 (1974).

    Article  CAS  Google Scholar 

  5. Rothman, J. E., and Engelman, D. M., Nature new Biol., 237, 42 (1972).

    Article  CAS  Google Scholar 

  6. Szabo, G., Eisenman, G., McLaughlin, S. G. A., and Krasne, S., Ann. N. Y. Acad. Sci., 195, 273 (1972).

    Article  ADS  CAS  Google Scholar 

  7. Muller, P., Rudin, D. O., Tien, H. T., and Wescott, W. C., Circulation, 26, 1167 (1962).

    Article  Google Scholar 

  8. Sims, P. J., Waggoner, A. S., Wang, C., and Hoffman, J. F., Biochemistry, 13, 3315 (1974).

    Article  CAS  Google Scholar 

  9. Ketterer, B., Neumcke, B., and Läuger, P., J. Membrane Biol., 5, 225 (1971).

    Article  CAS  Google Scholar 

  10. Bangham, A. D., cited in Szabo, G., and Eisenman, G., Biophys. Soc. Abstr., 13, 175a (1973).

    Google Scholar 

  11. Haydon, D. A., and Hladky, S. B., Quart. Rev. Biophys., 5, 187 (1972).

    Article  CAS  Google Scholar 

  12. Adam, N. K., The physics and chemistry of surfaces (Dover, New York, 1968).

    Google Scholar 

  13. Hall, J. E., Mead, C. A., and Szabo, G., J. Memb. Biol., 11, 75 (1973).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

SZABO, G. Dual mechanism for the action of cholesterol on membrane permeability. Nature 252, 47–49 (1974). https://doi.org/10.1038/252047a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/252047a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing