Abstract
INCLUSION of dimethylsulphoxide (DMSO) in the media of suspension cultures of Friend leukaemia cells (FLC) results in the erythroid differentiation of more than 50% of the cells1. This differentiation is demonstrated by morphological and biochemical alterations which are characteristic of normal erythroid maturation2–5. We report here that the differentiation of these leukaemic cells is accompanied by the development of responsiveness to erythropoietin (Ep), the physiological regulator of erythropoiesis.
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PREISLER, H., GILADI, M. Erythropoietin responsiveness of differentiating Friend leukaemia cells. Nature 251, 645–646 (1974). https://doi.org/10.1038/251645a0
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DOI: https://doi.org/10.1038/251645a0
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