Abstract
A QUANTUM mechanical analysis of Kier et al.1,2 indicates that the amine group of the catecholamine isoprenaline may not be essential to produce pharmacological effects mediated through adrenergic β receptors. Based on this and on conformational similarities between the ring, β-hydroxyl group and alkyl areas of N-n-propylnoradrenaline and prostaglandin (PG) E1, these authors predicted that PGE1 should be able to interact positively with adrenergic β receptors. Isolated tissues from kitten heart are appropriate systems to investigate effects of drugs which are β-receptor dependent and we tested the predictions of Kier et al. by investigating if PGE1 produced positive inotropic and chronotropic effects and whether these effects are transmitted through the adrenergic β receptors.
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KAUMANN, A., BIRNBAUMER, L. Prostaglandin E1 action on sinus pacemaker and adenylyl cyclase in kitten myocardium. Nature 251, 515–517 (1974). https://doi.org/10.1038/251515a0
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DOI: https://doi.org/10.1038/251515a0
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