Abstract
THE association of asbestos inhalation and lung disease has been recognised for many years1. Asbestosis is a chronic inflammatory reaction in the terminal bronchioles and alveoli of the lung with considerable fibrosis leading to distortion and eventual obliteration of the alveoli. There is also an association between asbestosis and the development of bronchogenic cancer2 and Wagner et al.3 have noted the occurrence of diffuse pleural and peritoneal mesotheliomas in individuals occupationally exposed to asbestos dust and in experimental animals following intrapleural injection of asbestos.
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References
Spencer, H., Pathology of the Lung (Second ed.), 434 (Pergamon Press, London, 1968).
Doll, R., Br. J. Ind. Med., 12, 81–86 (1955).
Wagner, J. C., Sleggs, C. A., and Marchand, P., Br. J. ind. Med., 17, 260–271 (1960).
Alison, A. C., Scientific Basis of Medicine Annual Reviews, 18–30 (1968).
Allison, A. C., and Davies, P., in Future Trends in Inflammation, (edit by Velo, G.), (University of Verona Press, in the press).
Suzuki, Y., Churg, J., and Ono, T., Am. J. Path., 69, 373–379 (1972).
Miller, K., and Harington, J. S., Br. J. exp. Path., 53, 397–405 (1972).
Page, R. C., Davies, P., and Allison, A. C., Arch. Oral Biol., 18, 1481–1496 (1973).
Cardella, C. J., Davies, P., and Allison, A. C., Nature, 247, 46–47 (1974).
Davies, P., Page, R. C., and Allison, A. C., J. exp. Med., 139, 1262–1282 (1974).
Page, R. C., Davies, P., and Allison, A. C., Lab. Invest., 30, 568–581 (1974).
Davies, P., Allison, A. C., Dym, M., and Cardella, C. J., in Infection and Immunology in the Rheumatic Diseases, (edit. by Dumonde, D. C.), (Blackwell, London, in the press).
Pinkett, M. O., Cowdrey, C. R., and Nowell, P. C., Am. J. Pathol., 48, 850–867 (1966).
Bowden, D. H., Adamson, I. Y. R., Grantham, W. G., and Wyatt, J. P., Arch. Path., 88, 540–546 (1969).
Woollen, J. W., Heyworth, R., and Walker, P. G., Biochem. J., 78, 111–116 (1961).
Talalay, P., Fishman, W. H., and Huggins, C., J. biol. Chem., 166, 752–772 (1946).
Conchie, J., Findlay, J., and Levvy, G. A., Biochem. J., 71, 318–325 (1959).
Morgenstern, W., Flor, R., Kessler, G., and Klein, B., Analyt. Biochem., 13, 149–161 (1965).
Harington, J. S., Miller, K., and Macnab, G., Environ. Res., 4, 95–117 (1971).
Harington, J. S., Allison, A. C., and Badami, D. V., Adv. Pharmac. Chemother. (in the press).
Satir, B., Schooley, C., and Satir, P., J. Cell Biol., 56, 153–176 (1973).
Allison, A. C., in Cell Interactions: Third Lepetit Colloquim, 156–161 (edit. by Silvestri, L. G.), (North Holland Publishing Co., Amsterdam, 1972).
McLachlan, M. S. F., and Wagner, J. C., Br. J. exp. Path., 55, 164–168 (1974).
Keller, R., J. exp. Med., 138, 625–644 (1973).
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DAVIES, P., ALLISON, A., ACKERMAN, J. et al. Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes. Nature 251, 423–425 (1974). https://doi.org/10.1038/251423a0
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DOI: https://doi.org/10.1038/251423a0
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