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Model for the regulation of mRNA translation applied to haemoglobin synthesis

Nature volume 251, pages 385–388 (1974)Cite this article

Abstract

A kinetic analysis of protein synthesis on ribosomes predicts that certain treatments which reduce the overall rate of polypeptide chain initiation wil inhibit translation preferentially of mRNAs with lower rate constants for polypeptide chain initiation. The effects of several inhibitors on α and β-globin synthesis by reticulocyte extracts agree with these predictions.

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Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139

    Harvey F. Lodish

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  1. Harvey F. Lodish
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Lodish, H. Model for the regulation of mRNA translation applied to haemoglobin synthesis. Nature 251, 385–388 (1974). https://doi.org/10.1038/251385a0

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