Abstract
Current theories of the crosslinks stabilising the collagen fibre are based on the isolation of compounds from borohydride-reduced collagen. What is the evidence for their existence in vivo and what, if any, is the physiological significance of these proposed crosslinks both in normal and pathological conditions?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bailey, A. J., Comprehensive Biochemistry (edit. by Florkin, M., and Stotz, E. H.), 26, 297–423 (Elsevier, Amsterdam, 1968).
Traub, W., and Piez, K. A., Adv. Protein Chem., 25, 243 (1971).
Bailey, A. J., and Robins, S. P., Frontiers in Matrix Biology (edit. by Robert, L.), 1, 130–153 (Karger, Basle, 1973).
Tanzer, M. L., Science, 180, 561 (1973).
Gallop, P. M., Blumenfeld, O. O., and Seifter, S., A. Rev. Biochem., 41, 617 (1972).
Bailey, A. J., Peach, C. M., and Fowler, L. J., in Chemistry and Molecular Biology of the Intercellular Matrix (edit. by Balazs, E. A.), 1, 385–404 (Academic Press, New York, 1969).
Bailey, A. J., and Peach, C. M., Biochem. biophys. Res. Commun., 33, 812 (1968).
Bailey, A. J., Biochim. biophys. Acta, 160, 447 (1968).
Robins, S. P., and Bailey, A. J., FEBS Lett., 38, 334 (1974).
Bailey, A. J., Fowler, L. J., and Peach, C. M., Biochem. biophys. Res. Commun., 35, 672 (1969).
Mechanic, G. L., Gallop, P. M., and Tanzer, M. L., Biochem. biophys. Res. Commun., 45, 644 (1971).
Davis, N. R., and Bailey, A. J., Biochem. biophys. Res. Commun., 45, 1416 (1971).
Bailey, A. J., Peach, C. M., and Fowler, L. J., Biochem. J., 117, 819 (1970).
Robins, S. P., Shimokomaki, M., and Bailey, A. J., Biochem. J., 131, 771 (1973).
Robins, S. P., and Bailey, A. J., FEBS Lett., 33, 167 (1973).
Eyre, D., and Glimcher, M. J., Biochem. biophys. Res. Commun., 295, 301 (1973).
Miller, E. J., Biochem. biophys. Res. Commun., 45, 444 (1971).
Balian, G., and Bailey, A. J., Biochem. J. (in the press).
Miller, E. J., J. biol. Chem., 248, 1666 (1973).
Hodge, A. J., and Petruska, J., in Aspects of Protein Structure (edit. by Ramachandran, G. A.), 289–306 (Academic Press, New York, 1963).
Tanzer, M. L., Housley, T., Berube, L., Fairweather, R., Franzblau, C., and Gallop, P. M., J. biol. Chem., 248, 393 (1973).
Robins, S. P., and Bailey, A. J., Biochem. J., 135, 657 (1973).
Brand, K., Tsolas, O., and Horecker, B. L., Archs Biochem. Biophys., 130, 521 (1969).
Schauer, R., Hoppe-Seylers Z. Physiol., 352, 1517 (1971).
Bailey, A. J., and Peach, C. M., Biochem. J., 121, 257 (1971).
Tanzer, M. L., and Mechanic, G., Biochem. biophys. Res. Commun., 39, 182 (1970).
Levene, C. I., Bates, C. J., and Bailey, A. J., Biochim. biophys. Acta, 263, 574 (1972).
Fairweather, R. B., Tanzer, M. L., and Gallop, P. M., Biochem. biophys. Res. Commun., 48, 1311 (1972).
Tanzer, M. L., Fairweather, R. B., and Gallop, P. B., Biochim. biophys. Acta, 310, 130 (1973).
Robins, S. P., and Bailey, A. J., Biochem. biophys. Res. Commun., 48, 76 (1972).
Tanzer, M. L., Fairweather, R., and Gallop, P. M., Archs Biochem. Biophys., 151, 137 (1972).
Kang, A. H., Piez, K. A., and Gross, J., Biochemistry, 8, 1506 (1969).
Kang, A. H., Igarashi, S., and Gross, J., Biochemistry, 8, 3200 (1969).
Barnes, M. J., Constable, B. J., Morton, L. F., and Kodicek, E., Biochem. J., 125, 925 (1971).
Barnes, M. J., in Hard Tissue Growth, Repair and Remineralisation, Ciba Foundation Symposium II, 247–261 (Elsevier, Amsterdam, 1973).
Miller, E. J., Lane, J. M., and Piez, K. A., Biochemistry, 8, 30 (1969).
Bailey, A. J., and Robins, S. P., FEBS Lett., 21, 330 (1972).
Bailey, A. J., Bazin, S., and Delauney, A., Biochim. biophys. Acta, 328, 383 (1973).
Sinex, F. M., Treatise on Collagen (edit. by Ramachandran, G. N.), 2 B, 410–448 (Academic Press, New York, 1968).
Lent, A., and Franzblau, C., Biochem. biophys. Res. Commun., 26, 43 (1967).
Mechanic, G. L., Gallop, P. M., and Tanzer, M. L., Biochem. biophys. Res. Commun., 45, 644 (1971).
Deshmukh, K., and Nimmi, M. E., Biochem. biophys. Res. Commun., 46, 175 (1972).
McKusick, V. A., Heritable Disorders of Connective Tissue (Mosby, St Louis, 1972).
Beighton, P., The Ehlers-Danlos Syndrome (Heineman Medical, London, 1970).
Krane, S. M., Pinnell, S. R., and Erbe, R. W., Proc. natn. Acad. Sci U.S.A., 69, 2899 (1972).
Eyre, D. R., and Glimcher, M. J., Proc. natn. Acad. Sci. U.S.A., 69, 2594 (1972).
Lichtenstein, J. R., Martin, G. R., Kohn, L. D., Byers, P. H., and McKusick, V. A., Science, 182, 298 (1973).
Lenears, A., Ansay, M., Nusgens, B. V., and Lapiere, C. M., Eur. J. Biochem., 23, 535 (1971).
Bailey, A. J., and Lapiere, C. M., Eur. J. Biochem., 34, 91 (1973).
Danks, D. M., Cambell, P. E., Walker-Smith, J., Stevens, B. J., Gillespie, J. M., Blomfield, J., and Turner, B., Lancet, i, 110 (1972).
Siegel, R. C., Pinnel, S. R., and Martin, G. R., Biochemistry, 9, 4486 (1970).
Laitinen, O., Uitto, J., and, Iivanainen, M., Clin. chim. Acta, 21, 321 (1968).
Priest, R. E., Moinuddi, J. F., and Priest, J. H., Nature, 245, 264 (1973).
Layman, D. L., Narayanan, A. S., and Martin, G. R., Archs Biochem. Biophys., 149, 97 (1972).
Herbert, C. M., Jayson, M. I. V., Beighton, P., and Bailey, A. J. (in preparation).
Herbert, C. M., Lindberg, K. A., Jayson, M. I. V., and Bailey, A. J., Lancet, i, 187 (1974).
Barnes, M. J., in Hard Tissue Growth, Repair and Remineralisation, 247–261 (Associated Scientific Press, Amsterdam, 1973).
Beisswenger, P. J., and Spiro, R. G., Science, 168, 596 (1970).
Kang, A. H., and Trelstad, R. L., J. clin. Invest., 52, 2571 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bailey, A., Robins, S. & Balian, G. Biological significance of the intermolecular crosslinks of collagen. Nature 251, 105–109 (1974). https://doi.org/10.1038/251105a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/251105a0
This article is cited by
-
Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes
Scientific Reports (2022)
-
Biochemical, structural and physical changes in aging human skin, and their relationship
Biogerontology (2022)
-
Autologous microfragmented adipose tissue reduces inflammatory and catabolic markers in supraspinatus tendon cells derived from patients affected by rotator cuff tears
International Orthopaedics (2021)
-
Effect of Ionic Liquids on the Fibril-Formation and Gel Properties of Grass Carp (Ctenopharyngodon idellus) Skin Collagen
Macromolecular Research (2018)
-
In Vitro Fabrication and Physicochemical Properties of a Hybrid Fibril from Xenogeneic Collagens
Food Biophysics (2017)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.