Abstract
ALTHOUGH it contradicts current dogma, there is considerable indirect evidence for the idea that most antibody diversity is generated only after B cells are stimulated to proliferate by antigens or mitogens1–3. A prediction of this theory, confirmed here, is that there may be rapid production within single clones, of cells producing antibody of different specificities.
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CUNNINGHAM, A., FORDHAM, S. Antibody cell daughters can produce antibody of different specificities. Nature 250, 669–671 (1974). https://doi.org/10.1038/250669a0
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DOI: https://doi.org/10.1038/250669a0
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