Abstract
DURING the past few years, it has become increasingly apparent that nonpeptide hormone action in the respective target organs occurs in the nucleus. This was first shown for steroid hormones1–4 and more recently for thyroid hormones5. Specific nuclear acceptor molecules for hormones have been shown in target tissues, associated with nuclear proteins6–8. The question arises whether hormone molecules, on their way to the nuclear binding sites, traverse the cytoplasm in a more or less random fashion or whether they are bound by specific cytoplasmic receptor molecules.
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STERLING, K., SALDANHA, V., BRENNER, M. et al. Cytosol-binding protein of thyroxine and triiodothyronine in human and rat kidney tissue. Nature 250, 661–663 (1974). https://doi.org/10.1038/250661a0
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DOI: https://doi.org/10.1038/250661a0
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