Abstract
IT is exceedingly rare for neoplasms to be invasive and metastatic when grafted in xenogeneic hosts1. During the past 7 yr, we have on numerous occasions observed the production of invasive and metastatic tumours in hamsters soon after injecting human cancer cells of diverse histopathology into their cheek pouches2–7. We have interpreted this biological phenomenon as due to the in vivo fusion of the human tumour with normal hamster host cells2–8, although the involvement of oncogenic viruses was not excluded. Recently, other evidence supporting the hybridisation of tumour with normal cells in vivo has appeared9. The significance of such events in the neoplastic process, however, has yet to be appreciated.
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GOLDENBERG, D., PAVIA, R. & TSAO, M. In vivo hybridisation of human tumour and normal hamster cells. Nature 250, 649–651 (1974). https://doi.org/10.1038/250649a0
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DOI: https://doi.org/10.1038/250649a0
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