Abstract
DNA repair-deficient microbial systems have attracted considerable attention because they offer an insight into the genetic control of sensitivity towards mutagens and carcinogens1. These studies have become highly relevant to man with Cleaver's discovery2 that cells of most patients with xeroderma pigmentosum (XP) have a reduced level of DNA repair synthesis following ultraviolet-irradiation or exposure to several chemical carcinogens3–6. The impaired repair capacity of XP cells seems to result in their greater sensitivity towards the lethal6–10 and chromosome-damaging action11–12 of those physical and chemical carcinogens which induce irreparable DNA alterations. On the other hand the behaviour of XP cells does not differ from that of controls when treated with several potent alkylating mutagens and carcinogens5,10,12,13.
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STICH, H., STICH, W. & LAM, P. Susceptibility of xeroderma pigmentosum cells to chromosome breakage by adenovirus type 12. Nature 250, 599–601 (1974). https://doi.org/10.1038/250599a0
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DOI: https://doi.org/10.1038/250599a0
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