Abstract
USING the double sucrose gap method, Bülbring and Tomita2 have shown that adrenaline hyperpolarises the membrane and reduces the electrotonic potential produced by constant current pulses in the guinea pig taenia coli muscle. They concluded, from the effects of membrane polarisation and changing external ionic composition on the adrenaline action, that an increase in the K and Cl conductances of the membrane is responsible for the hyperpolarisation.
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References
Abe, Y., and Tomita, T., J. Physiol., Lond., 196, 87–100 (1968).
Bülbring, E., and Tomita, T., Proc. R. Soc. Lond., B 172, 89–102 (1969).
Tomita, T., J. Physiol., Lond., 183, 450–468 (1966).
Inomata, H., and Kao, C. Y., J. Physiol., Lond., 226, 53–54P (1972).
Jenkinson, D. H., and Morton, I. K. M., J. Physiol., Lond., 188, 373–386 (1967).
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TOMITA, T., SAKAMOTO, Y. & OHBA, M. Conductance increase by adrenaline in guinea pig taenia coli studied with voltage clamp method. Nature 250, 432–433 (1974). https://doi.org/10.1038/250432a0
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DOI: https://doi.org/10.1038/250432a0
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