Abstract
FIBROBLASTS from patients with Fanconi's anaemia (FA) show increased susceptibility to transformation in vitro by SV40 virus1, as well as spontaneous chromosome breakage2. Chromosomal instability has also been observed in cultured peripheral blood lymphocytes and in bone marrow cells3. More recently, Sasaki and Tonomura4 demonstrated an increased susceptibility of lymphocytes from patients with FA to chromosome breakage by DNA cross linking agents. These results were interpreted as an indication that FA cells are defective in some DNA repair mechanism.
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POON, P., O'BRIEN, R. & PARKER, J. Defective DNA repair in Fanconi's anaemia. Nature 250, 223–225 (1974). https://doi.org/10.1038/250223a0
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DOI: https://doi.org/10.1038/250223a0
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