Abstract
THERE is considerable evidence that hormone secretion from the neurohypophysis occurs by exocytosis of neurosecretory granules present in the nerve terminals1–4. Exocytosis involves fusion of the granule membrane with the plasma membrane so that the entire soluble content of the granule is discharged into the extracellular space. Persistent hormone secretion does not lead to irreversible expansion of the plasmalemma of neurosecretory terminals, so the granule membrane must somehow be retrieved after fusion. There is morphological evidence based on the use of electron dense markers in various preparations, that following exocytosis membrane is returned to the cell interior where it is present as microvesicles and larger cisternae5–10.
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NORDMANN, J., DREIFUSS, J., BAKER, P. et al. Secretion-dependent uptake of extracellular fluid by the rat neurohypophysis. Nature 250, 155–157 (1974). https://doi.org/10.1038/250155a0
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DOI: https://doi.org/10.1038/250155a0
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