Abstract
ACTIVATION of the complement cascade (C1–C9) by the classic or alternate pathways is associated with the development of several biological activities1. These include the elaboration of chemotactic factors (C3a, C5a, and a trimolecular complex C&5,6,7bar;), opsonic activity associated with the formation of C3b from the third component, anaphylatoxin activity associated with the formation of C3a and C5a from the third (C3) and fifth (C5) components, and lysis of certain cells after the formation of lesions at the cell surface associated with fixation of the eighth (C8) and ninth (C9) components. We have detected another activity which follows intravascular activation of the complement cascade with the elaboration of the low molecular weight factor that produces an immediate neutropenia followed by marked neutrophilia.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ruddy, S., Gigli, I., and Austin, K. F., New Engl. J. Med., 248, 489, 545, 592, 624 (1972).
Ballow, M., and Cochrane, C. G., J. Immun., 103, 944 (1969).
Lachmann, P. J., Hobart, N. J., and Aston, W. P., in Experimental immunology, second ed. (edit. by Weir, P. M.), (Blackwell, Oxford, in the press).
Brown, D. L., dissertation, Univ. Cambridge (1972).
Cochrane, C. G., Müeller-Eberhard, H. J., and Akin, B. S., J. Immun., 105, 55 (1970).
Andrewes, F. W., Lancet, i, 8 (1910).
McCabe, W. R., New Engl. J. Med., 288, 21 (1973).
McKay, D. G., Thrombos. Diathes. Haemorrah., 22, 11 (1973).
Gilbert, D. N., Barnett, J. A., and Sanford, J. P., J. clin. Invest., 52, 406 (1973).
Dodds, W. J., and Pickering, R. J., Blood, 40, 400 (1972).
Rother, K., Eur. J. Immun., 2, 550 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MCCALL, C., DE CHATELET, L., BROWN, D. et al. New biological activity following intravascular activation of the complement cascade. Nature 249, 841–843 (1974). https://doi.org/10.1038/249841a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/249841a0
This article is cited by
-
Effects of dietary arachidonic acid on human immune response
Lipids (1997)
-
Maleic anhydride copolymers as synthetic activators of complement systems
Pharmaceutical Chemistry Journal (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.