Abstract
HISTAMINE receptors which are blocked by conventional antihistamines, such as mepyramine maleate, have been termed H1-receptors. Receptors which are not blocked by these drugs have been found in the cardiac atrium, the uterus and the gastric parietal cell1 and have been termed H2-receptors. An antagonist of these receptors (burim-amide) has recently been discovered2. Histamine H2-receptor antagonists inhibit gastric acid secretion stimulated by histamine, pentagastrin, hypoglycaemia and food in the dog (M. I. Grossman and S. J. Konturek, unpublished) and by histamine and pentagastrin in cat (S. J. Konturek, unpublished), pig (G.O.B., M. W. Waterworth, M. D., and S. B., unpublished), and man3. Studies have shown that some hormonal inhibitors of gastric acid secretion, namely secretin4 and glucagon5,6, depress fasting serum gastrin levels in man and a common mechanism of action through suppression of gastrin-mediated acid release has been postulated. This study attempts to determine whether burimamide has any effect on gastric acid secretion and gastrin release in basal conditions in the dog.
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BARBEZAT, G., DANIEL, M., BANK, S. et al. Effect of histamine H-receptor blockade on fasting serum gastrin and fasting gastric acid secretion in the dog. Nature 249, 666–668 (1974). https://doi.org/10.1038/249666a0
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DOI: https://doi.org/10.1038/249666a0
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