Abstract
ASSUMING that morphine induces dependence in response to continued interaction of the drug with an unidentified biochemical process of neurones, then suitable pharmacological manipulation might produce a paradigm of the morphine abstinence syndrome in experimental animals not exposed to any opiate. If so, the way in which such a quasi-abstinence syndrome was produced might throw light on the endogenous biochemical process involved1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Collier, H. O. J., Pharmacology, 11, 58–61 (1974).
Beer, B., Chasin, M., Clody, D. E., Vogel, J. R., and Horovitz, Z. P., Science, 176, 428–430 (1972).
Ho, I. K., Loh, H. H., and Way, E. L., J. Pharmac. exp. Ther., 185, 347–357 (1973).
Villarreal, J. E., and Dummer, G.E., Fedn. Proc., 32, 688 (1973).
Schulz, R., and Goldstein, A., Nature, 244, 168–169 (1973).
Collier, H. O. J., Francis, D. L., and Schneider, C., Nature, 237, 220–223 (1972).
Contreras, E., Castillo, S., and Quaida, L., J. Pharm. Pharmac., 24, 65–66 (1972).
Ho, I. K., Loh, H. H., and Way, E. L., J. Pharmac. exp. Ther., 185, 336–346 (1973).
Clark, A. G., Jovic, R., Ornellas, M. R., and Weller, M., Biochem. Pharmac., 21, 1989–1990 (1972).
Collier, H. O. J., Adv. Drug Res., 3, 171–188 (1966).
Palmer, G. C., Sulser, F., and Robison, G. A., Neuropharmacology, 12, 327–337 (1973).
Collier, H. O. J., and Roy, A. C., Nature, 248, 24–27 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
COLLIER, H., FRANCIS, D., HENDERSON, G. et al. Quasi morphine-abstinence syndrome. Nature 249, 471–473 (1974). https://doi.org/10.1038/249471a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/249471a0
This article is cited by
-
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice
Psychopharmacology (2006)
-
Inhibition of calcium channels by opioid‐ and adenosine‐receptor agonists in neurons of the nucleus accumbens
British Journal of Pharmacology (2001)
-
Adenosine receptor agonists attenuate and adenosine receptor antagonists exacerbate opiate withdrawal signs
Psychopharmacology (1996)
-
Differential effects of L-type calcium channel blockers and stimulants on naloxone-precipitated withdrawal in mice acutely dependent on morphine
Psychopharmacology (1991)
-
Long-term effects of neonatal exposure to isobutylmethylxanthine
Psychopharmacology (1991)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.