Abstract
ALPHA foetoprotein (αFP) is an α-globulin present in foetal and early postnatal sera of various animal species. It is not normally detectable in adult serum by the immunodiffusion test, but in several pathological conditions, particularly primary hepatomas, the level of αFP increases to a significant level. The potential use of this phenomenon in early diagnosis of hepatomas has been explored. These and related studies on αFP and other ‘foetal-tumour antigens’ have been reviewed recently1–5.
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References
Abelev, G. I., Adv. Cancer Res., 14, 295 (1971).
Uriel, J., Path. Biol., 17, 877 (1969).
Alexander, P., Nature, 235, 137 (1972).
Masseyeff, R., Path. Biol., 20, 703 (1972).
Anderson, N. G., and Coggin, jun., J. H., in Embryonic and Fetal Antigens in Cancer (edit. by Anderson, N. G., Coggin, jun., J. H., Cole, E., and Holleman, J. W.), 2, 361 (National Technical Information Service, U.S. Department of Commerce, Springfield, Virginia, 1972).
Gustine, D. L., and Zimmerman, E. F., Biochem. J., 132, 541 (1973).
Hill, H. Z., Wilson, S. H., and Hoagland, M. B., Biochim. biophys. Acta, 269, 477 (1972).
Abelev, G. I., Perova, S. D., Khramkova, N. I., Postnikova, Z. A., and Irlin, I. S., Transplantation, 1, 174 (1963).
Taylor, J. M., and Schimke, R. T., J. biol. Chem., 248, 7661 (1973).
Shafritz, D. A., J. biol. Chem., 249, 81 (1974).
Faber, A. J., Miall, S. H., and Tamaoki, T., Can. J. Biochem., (in the press).
Davis, B. J., Ann. N.Y. Acad. Sci., 121, 404 (1964).
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TAMAOKI, T., THOMAS, K. & SCHINDLER, I. Cell-free studies of developmental changes in synthesis of α-foetoprotein and albumin in the mouse liver. Nature 249, 269–271 (1974). https://doi.org/10.1038/249269b0
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DOI: https://doi.org/10.1038/249269b0
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