Abstract
BARBITURATES are commonly used to prevent epileptic seizures1, but it has also been observed that susceptibility to ‘spontaneous’ seizure in both normal humans and animals is increased during abrupt withdrawal from chronically administered barbiturates and other central nervous system depressants2. Here we show that barbiturate withdrawal is highly effective in producing audiogenic seizure susceptibility in a strain of mice which are normally resistant to seizure.
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GATES, G., CHEN, CS. Effects of barbiturate withdrawal on audiogenic seizure susceptibility in BALB/c mice. Nature 249, 162–164 (1974). https://doi.org/10.1038/249162a0
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DOI: https://doi.org/10.1038/249162a0
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