Abstract
Damaged nerves attempt to regenerate. The nerve membrane changes its properties, becomes spontaneously active and may be the source of pain. These impulse generators have unusual properties. They become silent after high frequency activity. This silence may partially explain the effect of counterstimulation as a pain therapy.
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References
Cajal, S. R., Degeneration and regeneration in the nervous system (Oxford University Press, London, 1928).
Diamond, J., J. Physiol., Lond., 145, 611 (1959).
Waxman, S. G., and Wall, P. D., Neurology, 23, 295 (1973).
Basbaum, A. I., Expl Neurol. (in the press).
Catton, W. T., J. Physiol., Lond., 141, 305 (1958).
Wall, P. D., and Johnson, A. J., Neurophysiology, 21, 148 (1958).
Wall, P. D., and Wickelgren, B., J. Physiol., Lond., 196, 135p (1968).
Wall, P. D., and Sweet, W. H., Science, 155, 108 (1967).
Melzack, R., and Wall, P. D., Science, 150, 971 (1965).
Campbell, J. N., and Taub, A., Arch. Neurol., 28, 347 (1973).
Wall, P. D., Handbook of Sensory Physiology, 2, 253 (Springer-Verlag, Berlin, 1973).
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Wall, P., Gutnick, M. Properties of afferent nerve impulses originating from a neuroma. Nature 248, 740–743 (1974). https://doi.org/10.1038/248740a0
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DOI: https://doi.org/10.1038/248740a0
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