Abstract
Chimaeras have been derived from aggregation of normal and dystrophic mouse embryos which had healthy muscles of almost totally dystrophic genotype, and diseased muscles of normal genotype. These results suggest that extramuscular factors must be implicated in muscular dystrophy.
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References
McComas, A. J., Sica, R. E. P., and Campbell, M. H., Lancet i, 321–325 (1971).
Gallup, B., and Dubowitz, B., Nature, 243, 287–289 (1973).
Salafsky, B., Nature, 299, 270–272 (1971).
Tarkowski, A. K., Nature, 190, 857–860 (1961).
Shows, T. B., Chapman, V. M., and Ruddle, F. H., Biochem. Genet., 4, 707–718 (1970).
Meier, H., and Southard, J. L., Life Sci., 9, 137–144 (1970).
Shows, T. B., and Ruddle, F. H., Science, 160, 1356–1357 (1968).
Engle, W., and Wolfe, U., Humangenetik, 12, 162–166 (1971).
Baker, W. B., and Mintz, B., Biochem. Genet., 2, 351–360 (1969).
Gearhart, J. D., and Mintz, B., Devl. Biol., 29, 27–37 (1972).
Emery, A. E. H., Lancet, i, 884 (1964).
Tsuyuki, H., Roberts, E., Kerr, R. H., and Ronald, A. P., J. Fish. Res. Bd Can., 23, 929–933 (1966).
Henderson, N. S., Archs Biochem. Biophys., 117, 28–33 (1966).
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Peterson, A. Chimaera mouse study shows absence of disease in genetically dystrophic muscle. Nature 248, 561–564 (1974). https://doi.org/10.1038/248561a0
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DOI: https://doi.org/10.1038/248561a0
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