Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Rosette formation by a mouse fibroblast cell line

Abstract

THE properties and activities of mammalian cell membranes have become an area of increasing interest in cell biology, and their study has involved a variety of experimental approaches. The mutual interaction of membranes from identical or different cell types has often been studied. For example, it has been found that a large proportion of human peripheral blood lymphocytes, when mixed with sheep red blood cells, form cell clusters known as rosettes, in which a central tymphocyte is partially or fully surrounded by red cells1–3. This also occurs with human thymocytes4, and is apparently a property of human lymphocytes derived from the thymus (T cells)5,6.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Brain, P., Gordon, J., and Willetts, W. A., Clin. exp. Immun., 6, 681 (1970).

    CAS  Google Scholar 

  2. Lay, W. H., Mendes, N. F., Bianco, C., and Nussenzweig, V., Nature, 230, 531 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Coombs, R. R. A., Gurner, B. W., Wilson, A. B., Holm, G., and Lindgren, B., Int. Archs Allergy, 39, 658 (1970).

    Article  CAS  Google Scholar 

  4. Nussenzweig, V., in Cell Interactions and Receptor Antibodies in Immune Responses (edit. by Mäkelä, O., and Kosunen, T. U., 449 (Academic, New York and London, 1971).

    Google Scholar 

  5. Fröland, S. G., Scand. J. Immun., 1, 269 (1972).

    Article  Google Scholar 

  6. Jondal, M., Holm, G., and Wigzell, H., J. exp. Med., 136, 207 (1972).

    Article  CAS  Google Scholar 

  7. Tønder, O., and Thunold, S., Scand. J. Immun., 2, 207 (1973).

    Article  Google Scholar 

  8. Littlefield, J. W., Proc. natn. Acad. Sci., U.S.A. 50, 568 (1963).

    Article  ADS  CAS  Google Scholar 

  9. Connors, T. A., and Jones, M., Recent Results Cancer Res., 33, 181 (1970).

    Article  CAS  Google Scholar 

  10. Davidson, R., Expl. Cell Res., 55, 424 (1969).

    Article  CAS  Google Scholar 

  11. Phillips, B. J., and Ambrose, E. J., Nature new Biol., 231, 146 (1971).

    Article  CAS  Google Scholar 

  12. Yoshida, T. O., and Andersson, B., Scand. J. Immun., 1, 401 (1972).

    Article  CAS  Google Scholar 

  13. Haskill, J. S., Elliott, B. E., Kerbel, R., Axelrad, M. A., and Eidinger, D., J. exp. Med., 135, 1410 (1972).

    Article  CAS  Google Scholar 

  14. Elliott, B. E., and Haskill, J. S., Eur. J. Immun., 3, 68 (1973).

    Article  CAS  Google Scholar 

  15. Wybran, J., and Fudenberg, H. H., J. clin. Invest., 52, 1026 (1973).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ELLIOTT, E., KERBEL, R. & PHILLIPS, B. Rosette formation by a mouse fibroblast cell line. Nature 248, 514–515 (1974). https://doi.org/10.1038/248514a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/248514a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing