Abstract
THE rate of protein synthesis in eukaryotic cells can change rapidly as a result of translational control such as the inhibition of protein synthesis during mitosis1 or starvation2–4. Under these conditions a reversible inhibition of the initiation step of protein synthesis decreases the rate at which ribosomes become attached to messenger RNA. The continuing runoff of ribosomes from messenger during protein chain elongation and termination depletes the percentage of the total ribosomes which are in the form of polysomes and are synthesising protein.
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KLEMPERER, H., ROSE, V. Decrease of polysomes in Tetrahymena after synchronisation shocks. Nature 248, 443–446 (1974). https://doi.org/10.1038/248443a0
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DOI: https://doi.org/10.1038/248443a0
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