Abstract
THE rates of cellular RNA and DNA synthesis decline during the mitotic stages of cell division1 and during cell differentiation2. The molecular mechanisms mediating such a decline may include changes in the size of mononucleotide pools, changes in RNA and DNA polymerase activity, or changes in DNA template activity3, but previous studies have not distinguished among these possibilities. We have developed a high-resolution electron microscopic technique for directly analysing DNA template activity within living cells4, and now report its application to individual cells undergoing division and differentiation in human bone marrow.
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NAKATSU, S., MASEK, M., LANDRUM, S. et al. Activity of DNA templates during cell division and cell differentiation. Nature 248, 334–335 (1974). https://doi.org/10.1038/248334a0
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DOI: https://doi.org/10.1038/248334a0
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